(Historical/Avengers West Coast#98 (fb) ) - Lucrezia Borgia was notorious for the poisoning of many of her enemies during the Italian Renaissance in the early sixteenth century.
(Tales of Suspense I#32/2 (fb)) - Lucrezia's family befriended the gypsy sorcerer Sazzik, and marveled at the mystical power he displayed.
(Avengers West Coast#100 (fb) - BTS) - After her death in 1519, she was consigned to Hell, specifically a branch controlled by the demon Mephisto.
(Mystic#6) - A man named Howard Mullins purchased a mirror that Lucrezia Borgia once owned. Supposedly, the mirror reflected the true character of the person reflected in it. He showed the mirror to his wife Karen....only to see a frightening image of a woman in the mirror. Concluding that his wife was dishonest, Mullins renounced her. Karen, distraught jumped to her death. Realizing he was wrong, Mullins went to smash the mirror....and saw Lucrezia Borgia laughing image on it.
(Avengers West Coast#98) - Another demon, Satannish, stole her soul, along with four others to create his Lethal Legion in an effort to gain vengeance on the Avengers West Coast for their previous defeat of him. Satannish imbued her with power, transforming her into Cyana, and promised her and her allies they could return to true life if they could bring him the souls of the Avengers West. Borgia participated in the brutal beating of US Agent.
(Avengers West Coast#99) - Then battled with Hangman WCA members Scarlet Witch and Hawkeye, while Axe of Vengeance slew Stella Houston, former lover of Hangman, as a diversion to allow other Legion members to abduct Mockingbird. She returned with all Lethal Legion members to Satannish's realm.
(Avengers West Coast#100) - As Satannish had planned, this drew the Avengers to his realm, where the Legion and Hangman defeated them. However, Mephisto had sneaked into Satannish's realm within the form of Hawkeye and attacked Satannish, demanding the stolen souls back. Borgia and the other members had their powers drained by Satannish to return himself to full power to battle Mephisto. Powerless, they were easily rounded up by the Avengers. However, Borgia and the rest of the Legion had their souls destroyed during Mephisto's and Satannish's struggle to obtain them.