While working as a chemist for Mainstream Motors, he created an "alchemy gun" capable of transmuting matter from one form to another by an unknown process (wood to glass, etc.). Horace Claymore, the company's president, was impressed until Curtis voiced his intent to keep the device. Claymore argued that since the gun was made on company time, it belonged to Mainstream. When Claymore fired him, Curtis adopted the persona of Chemistro to gain revenge and to extort his former employers.
In combat with Luke Cage, Chemistro accidentally fired his alchemy gun at his own foot, turning it to steel, though the unstable nature of the transmutation soon caused it to crumble to dust, leaving him crippled. He was turned over to the police, and in prison was beaten by his cellmate Arch Morton into revealing the means by which the alchemy gun worked.
Curtis Carr, as High-Tech, is being considered as a "potential recruit" for the Initiative program, according to Civil War: Battle Damage Report.
Curtis has been hired by the Hood to take advantage of the split in the superhero community caused by the Superhuman Registration Act.
Chemistro informs The Hood of a plot by Owl to sell Deathlok, which he stole from S.H.I.E.L.D., to the highest bidder. As Owl hasn't gained permission from his new crime syndicate, The Hood decides to gatecrash the auction. Sending Madame Masque, the Crimson Cowl, the Wizard, and Dr. Jonas Harrow as proxies he effortlessly ambushes and dispatches the Owl.
John King and The Hood reconvene in the back room of run-down bar where they are confronted by a curious Wolverine who overhears their plans to run Deathlok through the lobby of Avengers Tower. They escape by shooting Wolverine and assuming the form the Nistanti who originally owned his hood, using this form to escape.
Chemistro suggests that they change their plan and instead use Deathlok to rob a federal reserve bank under the Baxter Building. In the process they gain over 15 million in cash and lose Deathlok in the ensuing chaos.