Superman, Batman, the Martian Manhunter, John Stewart, Starfire, and Jason Blood are summoned to New Genesis.
Metron has discovered the Anti-Life Equation is a sentient being. It seeks to enter their dimension but can only send aspects of itself. These aspects seek to create enough chaos in order to instigate the Anti-Life's passage.
The aspects are destined for Earth, Rann, Thanagar, and Xanshi. If any two of the four planets are destroyed, the Milky Way will collapse. The heroes are sent to save the planets.