This issue established the fact of Vos' survival of Order 66--something which has huge implications for future Star Wars storytelling across the several Star Wars media outlets.
It was also the final issue of Republic--meaning that the series' major original star was allowed to survive, while almost all of Lucas' own characters were snuffed out by Order 66. (Well, okay, technically Vos is a Lucas creation, having appeared for less than a second in TPM prior to his first "real" appearance in Star Wars #19. But I dare ya to find him in Episode I. By contrast he's the undisputed "star" of Star Wars and Star Wars: Republic.)