J. Jonah Jameson hears rumors of a Lizard monster terrorizing the deep south, he puts up a reward for photos and Peter Parker volunteers. On arriving he meets Martha Connors, she tells him that the Lizard is her husband Curt. Spider-Man develops a cure for him and manages to feed it to the Lizard after a fight, curing him. He gets photos of Lizard but not Spider-Man and Jonah complains and they go back home.
Includes exclusive original comic book reproduction introducing the Lizard and an exclusive bonus DVD with behind-the-scenes, a trailer, and a sneak peek at a scene from the major motion picture The Amazing Spider-Man!