Moira, Mystique, Stryfe, Gordon Lefferts(? called 'Patient Zero') appear in flashback.
A long-running error in the series' indicia continues with this issue; although most of Marvel's titles are dated two months ahead of their publication date, Uncanny slipped backward a month. Although this issue was published in Jan. '01, and should be dated March '01, its indicia is labeled as Feb. '01. This "lost month" error continues until Uncanny #405 in '02.