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As the Red Skull receives a fitting funeral, the Avengers rush to save Captain America before he dies of old age. Using ISAAC's technology, Cap is subjected to a radiation treatment meant to reverse his artifial aging. In the middle of the process, Cap comes under attack by the Sisters of Sin! Will Cap be saved in time, and will the de-aging process also reverse the artificial aging on the Sisters of Sin?
Giant-Man, Iron Man, Namor, Thor, & Abraham Erskine appear in flashback.