Wong possessed by Nightmare! Dormammu and Umar in unholy alliance! The Hulk and the Sub-Mariner at each other's throats! The Silver Surfer...uh...surfing. Can Doctor Strange reunite the Defenders and save "Reality As We Know It?" Come to think of it, can editor Andy Schmidt save the Marvel Universe from Eisner-award-winning creators Keith Giffen, J.M. DeMatteis and Kevin Maguire? Only the Ancient One knows for sure!